1. Maus - Art Spiegalman (Pantheon)
2. Watchmen - Alan Moore & Dave Gibbons (DC)
3. The Dark Knight Returns - Frank Miller & Klaus Janson (DC)
4. Sandman - Neil Gaiman & Various Artists (DC)
5. All-Star Superman - Grant Morrison & Frank Quitely (DC)
6. Saga - Brian K. Vaughan & Fiona Staples (Image)
7. Hellboy - Mike Mignola (Dark Horse)
8. From Hell - Alan Moore & Eddie Campbell (Top Shelf)
9. Bone - Jeff Smith (Cartoon Books)
10. Batman: Year One - Frank Miller & David Mazzucchelli (DC)
11. V For Vendetta - Alan Moore & David Lloyd (Vertigo)
12. Preacher - Garth Ennis & Steve Dillon (Vertigo)
13. The Saga of The Swamp Thing - Alan Moore & Stephen Bissette (DC)
14. Uncanny X-Men - Chris Claremont & John Byrne (Marvel)
15. Y: The Last Man - Brian K. Vaughan & Pia Guerra (Vertigo)
16. Blankets - Craig Thompson (Top Shelf)
17. Marvels - Kurt Busiek & Alex Ross (Marvel)
18. Persepolis - Marjane Satrapi (L'Association)
19. Jimmy Corrigan, The Smartest Kid on Earth - Chris Ware (Pantheon)
20. Kingdom Come - Mark Waid & Alex Ross (DC)
21. Batman: The Killing Joke - Alan Moore & Brian Bolland (DC)
22. Batman: The Long Halloween - Jeph Loeb & Tim Sale (DC)
23. Daredevil - Frank Miller & Klaus Janson (Marvel)
24. Transmetropolitan - Warren Ellis & Darick Robertson (Vertigo)
25. Love and Rockets - Hernandez Brothers (Fantagraphics)
26. The Walking Dead - Robert Kirkman & Tony Moore (Image)
27. Fun Home: A Family Tragicomic - Alison Bechdel (Houghton Mifflin)
28. Akira - Katsuhiro Otomo (Kodansha)
29. Daytripper - Fábio Moon & Gabriel Bá (Vertigo)
30. Daredevil: Born Again - Frank Miller & David Mazzucchelli (Marvel)
31. Sin City - Frank Miller (Dark Horse)
32. Miracleman - Alan Moore & John Tottleben (Eclipse)
33. DC: The New Frontier - Darwyn Cooke (DC)
34. League of Extraordinary Gentlemen - Alan Moore & Kevin O'Neill (ABC)
35. Black Hole - Charles Burns (Fantagraphics)
36. A Contract With God - Will Eisner (Poorhouse Press)
37. Hawkeye - Matt Fraction & David Aja (Marvel)
38. Fables - Bill Willingham & Mark Buckingham (Vertigo)
39. Astro City - Kurt Busiek & Brent Anderson (Image)
40. The Amazing Spider-Man - Stan Lee & Steve Ditko (Marvel)
41. Scott Pilgrim - Bryan Lee O'Malley (Oni Press)
42. Whatever Happened To The Man of Tomorrow - Alan Moore & Curt Swan (DC)
43. New Teen Titans - Marv Wolfman & George Perez (DC)
44. Batman: Arkham Asylum - Grant Morrison & Dave McKean (DC)
45. Ghost World - Daniel Clowes (Fantagraphics)
46. Usagi Yojimbo - Stan Sakai (Dark Horse)
47. Crisis on Infinite Earths - Marv Wolfman & George Perez (DC)
48. Asterios Polyp - David Mazzucchelli (Pantheon)
49. X-Men: God Loves, Man Kills - Chris Claremont & Brent Anderson (Marvel)
50. Doom Patrol - Grant Morrison & Richard Case (DC)
51. The Infinity Gauntlet - Jim Starlin & George Pérez, Ron Lim (Marvel)
52. Nimona - ND Stevenson (Webcomic)
53. Planetary - Warren Ellis & John Cassaday (Wildstorm)
54. The Incal - Alejandro Jodorowsky & Jean Giraud (Les Humanoïdes Associés)
55. American Born Chinese - Gene Luen Yang (First Second)
56. My Favorite Thing Is Monsters - Emil Ferris (Fantagraphics)
57. Locke & Key - Joe Hill & Gabriel Rodríguez (IDW)
58. Understanding Comics - Scott McCloud (Tundra Publishing)
59. Superman: Red Son - Mark Millar & Various Artists (DC)
60. The Fantastic Four - Stan Lee & Jack Kirby (Marvel)
61. Blacksad - Juan Díaz Canales & Juanjo Guarnido (Dargaud)
62. Invincible - Robert Kirkman & Cory Walker, Ryan Ottley (Image)
63. March - John Lewis, Andrew Aydin & Nate Powell (Top Shelf)
64. Legion of Superheroes: The Great Darkness Saga - Paul Levitz & Keith Giffen, Larry Mahlstedt (DC)
65. The Mighty Thor - Walt Simonson & Sal Buscema (Marvel)
66. Criminal - Ed Brubaker & Sean Phillips (Image)
67. Sex Criminals - Matt Fraction & Chip Zdarsky (Image)
68. Animal Man - Grant Morrison & Chas Truog (DC)
69. Hellblazer - Various Artists & Writers (Vertigo)
70. Wolverine - Chris Claremont & Frank Miller (Marvel)
71. Nausicaä of the Valley of the Wind - Hayao Miyazaki (Tokuma Shoten)
72. Batman - Scott Snyder & Greg Capullo (DC)
73. Secret Wars - Jim Shooter & Mike Zeck, Bob Layton (Marvel)
74. 300 - Frank Miller & Lynn Varley (Dark Horse)
75. Civil War - Mark Millar & Steve McNiven (Marvel)
76. Astonishing X-Men - Joss Whedon & John Cassaday (Marvel)
77. The Invisibles - Grant Morrison & Various Artists (Vertigo)
78. Ms. Marvel - G. Willow Wilson & Adrian Alphona (Marvel)
79. Captain America - Ed Brubaker & Steve Epting (Marvel)
80. Berlin - Jason Lutes (Drawn & Quarterly)
81. Lone Wolf and Cub - Kazuo Koike & Goseki Kojima (Futabasha)
82. Superman For All Seasons - Jeph Loeb & Tim Sale (DC)
83. Calvin and Hobbes - Bill Watterson (Andrews McMeel Publishing)
84. Batman - Grant Morrison & Andy Kubert (DC)
85. The Vision - Tom King & Gabriel Hernandez Walta (Marvel)
86. 100 Bullets - Brian Azzarello & Eduardo Risso (Vertigo)
87. The Wicked + The Divine - Kieron Gillen & Jamie McKelvie (Image)
88. The Punisher Max - Garth Ennis & Laurence Campbell (Marvel)
89. Ultimate Spider-Man - Brian Michael Bendis & Mark Bagley (Marvel)
90. East of West - Jonathan Hickman & Nick Dragotta (Image)
91. Eightball - Daniel Clowes (Fantagraphics Books )
92. Kraven's Last Hunt - J. M. DeMatteis & Mike Zeck (Marvel)
93. Gotham Central - Ed Brubaker, Greg Ruka & Michael Lark (DC)
94. Batman: Hush - Jeph Loeb & Jim Lee (DC)
95. Hark! A Vagrant - Kate Beaton (Webcomic)
96. New X-Men - Grant Morrison & Frank Quitely (Marvel)
97. This One Summer - Mariko Tamaki & Jillian Tamaki (First Second)
98. Pluto - Naoki Urasawa & Takashi Nagasaki (Shogakukan)
99. Sweet Tooth - Jeff Lemire (Vertigo)
100. Essex County - Jeff Lemire (Top Shelf Productions)