25. Coming Home

Writer: J. Michael Straczynski

Artist: John Romita Jr.
Year: 1999

24. Death Of Spider-Man
Writer: Brian Michael Bendis
Artist: Mark Bagley
Year: 2011

23. Marvel Knights: Spider-Man

Writer: Mark Millar

Artist: Terry Dodson

Year: 2004-2005

22. Miles Morales: Ultimate Spider-Man
Writer: Brian Michael Bendis
Artist: Sara Pichelli
Year: 2014-2015

21. The Gauntlet

Writer: Various

Artist: Various

Year: 2009-2010

20. Maximum Carnage
Writer: Tom DeFalco, David Michelinie
Artist: Mark Bagley
Year: 1993

19. The Sinister Six

Writer: Stan Lee

Artist: Steve Ditko

Year: 1964

18. The Conversation
Writer: J. Michael Straczynski
Artist: John Romita Jr.
Year: 2002

17. A Death in the Family

Writer: J.M. DeMatteis

Artist: Mark Bagley

Year: 1995

16. Power and Responsibility
Writer: Brian Michael Bendis
Artist: Mark Bagley
Year: 2000

15. Superior Spider-Man

Writer: Dan Slott

Artist: Ryan Stegman

Year: 2013-2014

14. How Green Was My Goblin/Spidey Saves the Day
Writer: Stan Lee
Artist: John Romita Sr.
Year: 1966

13. Spider-Verse

Writer: Dan Slott

Artist: Olivier Coipel

Year: 2014-2015

12. The Hobgoblin Saga
Writer: Roger Stern
Artist: John Romita Jr.
Year: 1983

11. Best of Enemies

Writer: J.M. DeMatteis

Artist: Sal Buscema

Year: 1994

10.
Writer: David Michelinie
Artist: Todd McFarlane
Year: 1988

9. Nothing Can Stop the Juggernaut

Writer: Roger Stern

Artist: John Romita Jr.

Year: 1982

8. The Death of Jean DeWolff
Writer: Peter David
Artist: Rich Buckler
Year: 1985

7. Spider-Man: No More

Writer: Stan Lee

Artist: John Romita Sr.

Year: 1967

6. Spider-Man: Blue
Writer: Jeph Loeb
Artist: Tim Sale
Year: 2002-2003

5. The Kid Who Collects Spider-Man

Writer: Roger Stern

Artist: Ron Frenz

Year: 1984

4. If This Be My Destiny...!
Writer: Stan Lee
Artist: Steve Ditko
Year: 1965

3. Amazing Fantasy #15

Writer: Stan Lee

Artist: Steve Ditko

Year: 1962

2. Kraven's Last Hunt
Writer: J.M. DeMatteis
Artist: Mike Zeck
Year: 1987